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Why did 54gene Fail?

What Happened to 54gene & Why Did It Fail?

January 25, 2025

54gene, co-founded by Dr. Abasi Ene-Obong in 2019, aimed to bridge the gap in global genomics by providing African genetic data for pharmaceutical research. Despite raising $45 million, the startup faced financial and leadership challenges, leading to its closure in September 2023.

What Was 54gene?

54gene

54gene developed an online genetics platform to enhance drug discovery and clinical trials by utilizing African genetic data. Its unique value proposition was addressing the underrepresentation of African genetic material in global research. Notable achievements include raising $45 million and establishing a biobank with invaluable biological samples.

What Happened to 54gene?

The story of 54gene is a compelling narrative of rapid growth followed by a swift decline, marked by several critical phases:

  • Founding and Initial Mission: 54gene was established in 2019 with the goal of providing essential genomic data specific to African populations. This initiative aimed to enhance drug discovery procedures for international pharmaceutical firms, addressing the underrepresentation of African genetic material in global research.
  • Key Milestones: The company secured $45 million through three funding rounds, a testament to its promising potential. Co-founded by Dr. Abasi Ene-Obong, 54gene quickly became a notable player in the genomics field.
  • Leadership Instability: The company faced significant leadership changes, with three different CEOs in its last year of operations. This instability contributed to operational disarray, culminating in the replacement of its CEO in March 2023.
  • Financial Difficulties: Despite its initial success, 54gene could not sustain its financial viability, leading to its winding down in July 2023. The company is now seeking buyers for its assets, including a valuable biobank.
  • Eventual Decline: By September 2023, 54gene's website had become inaccessible, and its public relations agency had disassociated itself from the company. The sudden collapse of 54gene could discourage global investors from engaging in similar ventures, casting uncertainty over the health tech sector.

When Did 54gene Shut Down?

54gene began winding down its operations in July 2023, and by September, its website was no longer accessible. The shutdown was marked by financial difficulties, leadership instability, and unresolved legal issues.

Why Did 54gene Shut Down?

  1. Financial Difficulties: Despite raising $45 million, 54gene struggled to maintain financial stability. The company began winding down operations in July 2023 due to an inability to continue financially. As Ron Chiarello noted, “Unfortunately, the company could not continue to operate financially, and it began to wind down in July.”
  2. Leadership Instability: Frequent changes in leadership destabilized the company. Over the last year, 54gene saw three different CEOs, which led to operational disarray. This instability was a significant factor in the company's decline, culminating in the replacement of its CEO in March 2023.
  3. Legal Issues: The company faced unresolved legal claims from creditors and a lawsuit from former legal counsel and interim CEO Teresia Bost. These legal challenges complicated the sale of its assets and further strained its financial resources, contributing to its eventual shutdown.
  4. Hostile Work Environment: Allegations of discriminatory behavior and a hostile work environment led to a lawsuit, tarnishing the company's reputation. This legal battle not only diverted resources but also impacted employee morale and public perception.
  5. Market Challenges: The collapse of 54gene has broader implications for the genomics and health tech sector. The company's failure may discourage global investors from engaging in similar ventures, casting uncertainty over the future of health tech startups focused on African genetic data.

Lessons Learned from 54gene's Failure

  • Financial Management: Ensure robust financial planning and management to sustain operations, even after securing significant funding.
  • Stable Leadership: Maintain consistent and effective leadership to avoid operational disarray and ensure strategic continuity.
  • Legal Preparedness: Address legal issues promptly to prevent them from escalating and draining resources.
  • Workplace Culture: Foster a positive and inclusive work environment to maintain employee morale and protect the company's reputation.
  • Market Adaptability: Stay adaptable to market changes and challenges to remain competitive and viable.

We Shut Down Startups

54gene's failure underscores the complexities and challenges that startups face, from financial instability to legal issues. If you're navigating a similar situation, Sunset can help you manage the winding-down process efficiently.

Sunset takes care of all the legal, tax, and operational burdens, allowing you to avoid penalties and reduce liabilities. Book a demo today to see how we can assist you in moving on to your next venture seamlessly.